Human Monocytes - CD14, CD16 - Ziegler-Heitbrock

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Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients

Abstract

Monocyte phenotype and function were measured in whole blood sampled from a current cohort of human immunodeficiency virus (HIV)-infected individuals attending a large, metropolitan, university-affiliated hospital. There was no significant difference in the prevalence of CD16+ monocytes or the capacity of monocytes to ingest heat-killed Mycobacterium avium complex between these individuals and HIV-uninfected control subjects, regardless of viral load, current CD4+ T cell count, nadir CD4+ T cell count, or time since diagnosis of HIV infection. CD16+ monocyte prevalence was, however, elevated in patients not currently receiving antiretroviral therapy. We conclude that HIV type 1 infection in the setting of highly active antiretroviral therapy is associated with normal monocyte function and phenotype.

Authors: Jaworowski A, Ellery P, Maslin CL, Naim E, Heinlein AC, Ryan CE, Paukovics G, Hocking J, Sonza S, Crowe SM
Journal: J Infect Dis., 193(5):693-697
Year: 2006
PubMed: Find in PubMed